MULTIDRUG-RESISTANT KLEBSIELLA PNEUMONIA WITH COLISTININDUCED ACUTE KIDNEY INJURY IN A PATIENT WITH EMPHYSEMA: A CASE REPORT OF A 70 YEARS OLD MALE WITH INTEGRATIVE YOGA PRANA VIDYA (YPV) HEALING SUPPORT

Leelavathi Nayak, Venkata Satyanarayana Nanduri*

Background: Multidrug-resistant (MDR) Klebsiella pneumoniae infections pose significant therapeutic challenges, particularly in patients with chronic lung disease. Colistin remains a last-resort antibiotic but is associated with nephrotoxicity. Case Presentation: A 70-year-old male with emphysema, diabetes, and hypertension presented on 28 December 2025 with breathlessness, cough, fever, and weakness. Initial management with Tazobactam, Clindamycin, and later Meropenem failed to improve symptoms. On 5 January 2026, he was admitted to Manipal Hospital, Bangalore, with severe hypoxia requiring HFNC oxygen. Bronchoscopy on 9 January revealed MDR Klebsiella pneumoniae, sensitive only to Colistin and Tigecycline. IV Colistin, Tigecycline, and steroids were initiated, leading to clinical improvement and discharge on 14 January. By 19 January, blood tests revealed acute kidney injury attributed to Colistin. Colistin was discontinued, and Tigecycline continued for 12 days. Renal function normalized by 23 February. Chest X-ray on 29 January showed ~60% resolution of pneumonia. Oral steroids and inhalers were prescribed. By February 2026, the patient remained stable with oxygen saturation of 90% without support, though mild cough and weakness persisted. Parallel Yoga Prana Vidya (YPV) healing sessions were administered throughout hospitalization and recovery, reported by family to aid faster recovery. Conclusion: This case highlights the importance of culture-directed therapy in MDR pneumonia, vigilance for antibiotic-induced nephrotoxicity, and the potential adjunctive role of integrative healing practices in recovery.